Lupus Nephritis

Lupus nephritis is an inflammation of the kidney caused by systemic lupus erythematosus (SLE), a disease of the immune system. SLE causes harm to the skin, joints, kidneys, and brain.

The causes of SLE are unknown. Many factors may play a role, including

  • gender (SLE is more common in women than men)
  • heredity (a gene passed down by a parent)
  • infections
  • viruses
  • environmental causes

Some people with SLE may have no symptoms of kidney disease. However, lupus nephritis may cause weight gain, high blood pressure, dark urine, or swelling around the eyes, legs, ankles, or fingers.

Diagnosis may require urine and blood tests and x rays of the kidneys as well as a kidney biopsy. Treatment depends on the symptoms. Medicines can decrease swelling, lower blood pressure, and decrease inflammation by suppressing the immune system. Patients may need to limit protein, sodium, and potassium intake in their diet.

Lupus nephritis is a glomerular disease.

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