Perindopril

Coversyl (perindopril) is a long-acting ACE inhibitor. International nonproprietary name: Perindopril.

Indications

: Essential hypertension. Stable coronary artery disease: reduction of risk of cardiac events in patients with a history of myocardial infarction and/or revascularization. Treatment of symptomatic heart failure:

Dosage and administration

: Coversyl (perindopril) should be taken in the morning before food. Hypertension: 4 mg once daily, then the dose may be increased to 8 mg after 1 month of treatment to improve blood pressure control or in case of concomitant stable coronary artery disease. Stable coronary artery disease: A starting dose of 4 mg for 2 weeks is recommended, then uptitration to 8 mg once daily, depending on acceptability. Congestive heart failure: Coversyl (perindopril) should be started under close medical supervision at a starting dose of 2 mg. This may be increased to 4 mg once blood pressure acceptability has been demonstrated. Elderly patients: start treatment at 2 mg daily. Contraindications: Children. Pregnancy. Lactation. Patients with a history of hypersensitivity to Coversyl (perindopril).

Precautions

: Assess renal function before and during treatment where appropriate. Renovascular hypertension. Surgery/anaesthesia. Renal failure: the dose should be cautiously adjusted in accordance with the creatinine clearance (refer to complete data sheet). Symptomatic hypotension is rarely seen, but is more likely in volume-depleted patients, those receiving diuretics, or with the first two doses. In diuretic-treated patients, stop the diuretic 3 days before starting Coversyl (perindopril). A diuretic may later be given in combination if necessary; potassium-sparing diuretics are not recommended. Combination with neuroleptics or imipramine-type drugs may increase the hypotensive effect. Serum lithium concentrations may rise during lithium therapy.

Side effects

: Rare and mild, usually at the start of treatment. Cough, fatigue, asthenia, headache, disturbances of mood and/or sleep have been reported. Less often, taste impairment, epigastric discomfort, nausea, abdominal pain, and rash. Reversible increases in blood urea and creatinine may be observed. Proteinuria has occurred in some patients. Rarely, angioneurotic oedema and decreases in haemoglobin, red cells, and platelets have been reported.

Composition

: Each tablet contains 2 mg, 4 mg or 8 mg of the tert-butylamine salt of perindopril.

Presentation

: Packs of 30 tablets of Coversyl (perindopril) 2 mg. Packs of 30 tablets of Coversyl (perindopril) 4 mg (scored). Packs of 30 tablets of Coversyl (perindopril) 8 mg.

Also available under the brand names: Aceon ®, Acertil ®, Armix ®, Coverene ®, Coverex ®, Coversum ®, Prestarium ®, Prexanil ®, Prexum ®, Procaptan ®.

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