Carbinoxamine

Carbinoxamine is an H1 class antihistamine. It was first launched in the United States by the McNeil Corporation under the brand name Clistin. It is now available under the brand name Palgic as 4mg tablets or 4mg/5mL liquid. It is FDA approved (specifically at the 4mg dose/strength) for hay fever (a.k.a. allergic rhinitis, SAR and PAR); vasomotor rhinitis; mild urticaria; angioedema, dermatographism and allergic conjunctivitis.

Carbinoxmaine liquid is popular with children because the taste is very mild and easily swallowed. Palgic liquid is clear and has a bubble gum flavor.

website:www.palgic.com

In June, 2006 the FDA announced that more than 120 branded pharmacy products containing carbinoxamine were being illegally marketed and demanded they be removed from the marketplace. These products were unapproved (typically with inappropriate information on dosing and/or at various strengths that were unapproved) for use in the United States despite that fact that many doctors had prescribed them and that many pharmacies carried them on shelves. These brand names included Carbofed; Histex, Pediatex, Pediox, Mintex, Carbihist, Balamine, Andehist, Dmax, Cardec, Xirahist and Carbaxefed.

website:www.carbinoxamine.com

The effectiveness is outstanding. More than 80% of patinets trying 4mg carbinoxmaine in the original study, found the dose effective in providing relief from allergy symptoms. The most common side effect was mild sedation that affected approximately 15%-20% of the patients. All patients reported that the drowsiness went away after a day or two of use. Many patinets also report a superior "drying effect" with carbinoxamine over more modern antihistimes. Carbinoxamine competes with histamine for receptor sites on effector cells. The half-life is 10-20 hours (varies by person) and most patients use only one 4mg dose per day.

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