Cefradine
Cefradine (INN) or cephradine (former BAN) is a Ceftazidime (INN) is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria. Unlike most third-generation agents, it is active against Pseudomonas aeruginosa, however it has weaker activity against Gram-positive microorganisms and is not used for such infections. Ceftazidime pentahydrate is marketed under various trade names including Fortum (GSK).
Clinical use
Ceftazidime is usually reserved for the treatment of infections caused by Pseudomonas aeruginosa. It is also used in the empirical therapy of febrile neutropaenia, in combination with other antibiotics. The usual dose is 1–2 g IV/IM every 8–12 hours, though this can vary by the indication, infection severity, and/or renal function of the recipient.
Chemistry
In addition to the syn-configuration of the imino side chain, compared to other third-generation cephalosporins, the more complex moiety (containing two methyl and a carboxylic acid group) confers extra stability to β-lactamase enzymes produced by many Gram-negative bacteria. The extra stability to β-lactamases increases the activity of ceftazidime against otherwise resistant Gram-negative organisms including Pseudomonas aeruginosa. The charged pyridinum moiety increases water-solubility.first generation cephalosporin antibiotic.
MEDIC8®: a-z of diseases
Clinics & treatments
Medic8® Guides
- Cosmetic Surgery
- Cosmetic Dentistry
- Weight Loss Surgery
- Laser Eye Surgery
- Laser Hair Removal
- Health Insurance
- Life Insurance
- Family Health
- Travel Health
Health centres
- Allergies
- Alternative Health
- Arthritis
- Asthma
- Blood Disorders
- Bones & Joints
- Bowel & Abdominal Problems
- Cancer
- Chest Problems
- Child Health
- Circulation Problems
- Diabetes
- Diet & Nutrition
- Drug Addiction
- Ear, Nose, & Throat Problems
- Elderly Health
- Eye Problems
- Heart Problems
- High Blood Pressure
- Hormone & Endocrine Problems
- Infections
- Infertility
- Liver Problems
- Medications
- Men's Health
- Mental Health
- Nervous System
- Personal & Social Issues
- Pregnancy & Birth
- Preventive Health
- Radiology
- Sexual Health
- Skin Problems
- Sports Medicine
- Surgery
- Travel Health
- Urinary & Kidney Problems
- Vaccination
- Women's Health
