Griseofulvin

Griseofulvin is an antifungal drug. It is used both in animals and in humans, to treat ringworm infections of the skin and nails. It is derived from the mold Penicillium griseofulvum.

It is administered orally.

It binds to keratin in keratin precursor cells and makes them resistant to fungal infections. It is only when hair or skin is replaced by the keratin-griseofulvin complex that the drug reaches its site of action. Griseofulvin will then enter the dermatophyte through energy dependant transport processes and bind to fungal microtubules. This alters the processing for mitosis and also underlying information for deposition of fungal cell walls.

Known side effects:

  • Hives
  • Skin rashes
  • Confusion
  • Dizziness
  • diarrhoea
  • Fatigue
  • Headache
  • Impairment of performance of routine activities
  • Inability to fall or stay asleep
  • Nausea
  • Oral thrush (imflammation of the mouth)
  • Upper abdominal pain
  • Vomiting
  • Swelling
  • Itching
  • Tingling in the hands or feet
  • Loss of taste sensation

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