Indapamide

Indapamide is a thiazide diuretic drug, usually used in the treatment of hypertension and oedema caused by congestive heart failure.

Indapamide is marketed as NATRILIX SR®

NATRILIX SR abridged prescribing information

Form and Composition:

Each sustained-release coated tablet contains 1.5 mg of 1-(4-chloro-3-sulfamyl-benzamido)-2-methylindoline (or indapamide hemihydrate).

Indication:

Essential hypertension.

Contraindications:

Hypersensitivity to sulfonamides, Severe renal failure, Hepatic encephalopathy or severe hepatic failure, Hypokalemia.

Combination treatments:

Natrilix SR may be combined with all nonthiazide antihypertensive agents, with ß-blockers, calcium channel blockers, and ACE inhibitors.

Drug combinations to be avoided:

Lithium, nonantiarrhythmic drugs causing wave burst arrhythmia (astemizole, bepridil, IV erythromycin, halofantrine, pentamidine, sultopride, terfenadine, vincamine).

Precautions:

Pregnancy. Lactation. Monitoring of potassium and uric acid serum levels is recommended, especially in subjects with a predisposition or a sensitivity to hypokalemia and in patients with gout. Although no allergic manifestations have been reported during clinical trials, patients with a history of allergy to sulfonamide derivatives should be closely monitored.

Adverse effects

:

Hypokalemia, Fatigue, Orthostatic hypotension, Allergic manifestations.

Dosage and administration:

One tablet daily.

Overdosage:

Symptoms of overdosage would be those associated with a diuretic effect: electrolyte disturbances, hypotension, and muscular weakness. Treatment should be symptomatic, directed at correcting the electrolyte abnormalities.

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