Nialamide

Nialamide was one of the first MAOI (monoamine oxidase inhibitor) antidepressants. It is chemically related to iproniazide, another MAOI derived from isonicotinic acid.

Uses

Approved
Nialamide is effective for depression characterised by anergic symptoms, endogenous depression, and reactive depression.

Unapproved/Off-Label/Investigational
Nialamide is sometimes used in the treatment of trigeminal neuralgia. It has also been studied for alcoholism, dermatomally distributed vitiligo, irregular menstrual cycle,, angina, cerebrovascular disorders, and the prevention of streptomycin-induced deafness.

Side effects

Side effects of nialamide include insomnia, vertigo, hyperhidrosis, weight gain, vomiting, tachycardia, constipation, dry mouth, upset stomach, orthostatic hypotension and decreased systolic pressure.

Tradenames

Nialamide is sold under Psicodisten®, Niaquitil®, Nialamid®, Niamidal®, Niamide®, Novazid®, Nuredal®, Niamid® (Italy, Belgium, Netherlands, England, United States), Niazin®, Nyazin®, Surgex® (Italy), Mygal®, Delmoneurina®, Isalizina® (Italy), Espril® (Italy), and Nyezin®.

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