Danaparoid

Danaparoid sodium (Orgaran®) is an anticoagulant that works by inhibiting thrombin. It is used to prevent deep venous clots, particularly in situations with a high risk of clot formation, such as after hip surgery. It is also used as a heparinoid substitute in heparin-induced thrombocytopaenia which may otherwise cause paradoxical thrombosis. This drug is no longer marketed in the United States.

Administration

IV

Side effects

  • Bleeding problems
  • Low platelets, due to a low level of structural similarity between danaparoid and heparin
  • Asthma exacerbations, due to allergies to sulphites contained within the medicine

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