Oxazepam

Oxazepam (marketed under brand names Alepam®, Murelax®, Serax®, Serepax®, Seresta®) is a drug which is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties.

Pharmacology

Oxazepam is a metabolic by-product of diazepam.

Indications

It is an intermediate acting benzodiazepine with a slow onset of action, so it is usually prescribed to individuals who have trouble staying asleep, rather than falling asleep. It is commonly prescribed for anxiety disorders with associated tension, irritability, and agitation. It is also prescribed for drug and alcohol withdrawal, and for anxiety associated with depression.

Dosage

  • Mild/moderate anxiety - 10 to 15mg, 3 to 4 times daily
  • Severe anxiety - 15 to 30mg, 3 to 4 times daily
  • Symptoms related to alcohol withdrawal - 15 to 30mg, 3 to 4 times daily

    • Availability

    In the United Kingdom, oxazepam is available generically in the form of 10mg, 15mg and 30mg tablets.

    Side effects

    The side effects of oxazepam are similar in nature to those of other benzodiazepines.

    Side effects from oxazepam are common and include: drowsiness, dizziness, tiredness, weakness, dry mouth, diarrhoea, upset stomach, changes in appetite, heart palpitations, anxiety, trouble breathing, shortness of breath, angry outbursts, trouble sleeping, tremors

    Interactions

    As oxazepam is an active metabolite of diazepam, there is likely an overlap in possible interactions with other drugs or food.

    Overdose

    Symptoms of overdose include:

  • Somnolence
  • Confusion
  • Impaired motor function
  • Coma
  • Hypoventilation (respiratory depression)
  • Hypotension

    • Legal Status

    Oxazepam is a Schedule IV drug under the Convention on Psychotropic Substances.

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