Ropinirole

Ropinirole (marketed as Requip®) is a non-ergoline dopamine agonist, manufactured by GlaxoSmithKline. It is used in the treatment of Parkinson's disease, and is also the only medication in the United States with an FDA-approved indication for the treatment of restless legs syndrome.

Dosing

Requip (known as Adartrel in Europe) is available in various preparations, ranging from the .25mg tablet to the 5mg tablet. The primary reason for such is dose titration. This implies that the person taking ReQuip has to closely interact and communicate with the Personal Care Physician with regard to how much should actually be taken by the patient.

For Restless Legs Syndrome or RLS, the maximum recommended dose is 4mg per day, taken 1 to 3 hours before bedtime.

For Parkinson's Disease or PD, the maximum recommended dose is 24mg per day, taken in three separate doses spread throughout the day.

Parkison's Disease

Mechanism

Ropinirole binds to D3 receptors, acting as an agonist.

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