Oxazepam

Oxazepam (marketed under brand names Alepam®, Murelax®, Serax®, Serepax®, Seresta®) is a drug which is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties.

Pharmacology

Oxazepam is a metabolic by-product of diazepam.

Indications

It is an intermediate acting benzodiazepine with a slow onset of action, so it is usually prescribed to individuals who have trouble staying asleep, rather than falling asleep. It is commonly prescribed for anxiety disorders with associated tension, irritability, and agitation. It is also prescribed for drug and alcohol withdrawal, and for anxiety associated with depression.

Dosage

Mild/moderate anxiety - 10 to 15mg, 3 to 4 times daily

Severe anxiety - 15 to 30mg, 3 to 4 times daily

Symptoms related to alcohol withdrawal - 15 to 30mg, 3 to 4 times daily

Availability

In the United Kingdom, oxazepam is available generically in the form of 10mg, 15mg and 30mg tablets.

Side effects

The side effects of oxazepam are similar in nature to those of other benzodiazepines.

Side effects from oxazepam are common and include: drowsiness, dizziness, tiredness, weakness, dry mouth, diarrhoea, upset stomach, changes in appetite, heart palpitations, anxiety, trouble breathing, shortness of breath, angry outbursts, trouble sleeping, tremors

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Interactions

As oxazepam is an active metabolite of diazepam, there is likely an overlap in possible interactions with other drugs or food.

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Contraindications

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Overdose

Symptoms of overdose include:

Somnolence

Confusion

Impaired motor function

Coma

Hypoventilation (respiratory depression)

Hypotension

Legal Status

Oxazepam is a Schedule IV drug under the Convention on Psychotropic Substances .

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