Diethylcathinone

Diethylcathinone, also called Diethylpropion, is a sympathomimetic stimulant drug marketed as an appetite suppressant.

The popular antidepressant, Wellbutrin(bupropion) is a derivative of this chemical. Both diethypropion and bupropion have a stimulant effect on the CNS.

Its mechanism of action is similar to other appetite suppressants such as sibutramine, phentermine and dextroamphetamine. Chemically, it is the N,N-diethyl analog of cathinone and dimethylcathinone. Diethylpropion is manufactured in 25 mg tablets and 75 mg controlled-release tablets (Tenuate®, Tepanil Ten-Tab®). Diethylpropion is classified as a Schedule IV controlled substance in the United States.

It is also used in the treatment of migraine (off-label).

Contraindications:

Hypersensitivity to sympathomimetic amines
Advanced arteriosclerosis or symptomatic cardiovascular disease
Moderate or severe hypertension
Hyperthyroidism
History of drug abuse
MAO inhibitor use (within 14 days)

Side effects:

Severe:
Pulmonary hypertension
Stroke
Psychosis
Cardiovascular:

Tachycardia, hypertension, arrhythmia, chest pain
Ear, nose, and throat:

Xerostomia, metallic taste
Endocrine:

Changes in libido, gynaecomastia, menstrual irregularities
Eye:

Blurred vision
Gastrointestinal:

Nausea/vomiting, constipation, abdominal cramps
Hematological:

Bone marrow depression, agranulocytosis, leukopaenia
Neurological:

Tremor
Psychological:

Euphoria, agitation, nervousness, restlessness, dizziness, anxiety, headache, mental depression, seizures
Skin:

Rash, hives, alopecia, ecchymosis
Urogenital and reproductive:

Changes in libido, impotence

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