Vinpocetine

Vinpocetine (brand names: Cavinton, Intelectol; chemical name: ethyl apovincaminate) is a semisynthetic derivative of vincamine, which is extracted from the periwinkle plant. It increases cerebral blood flow and is said to improve memory.

It is an inhibitor of Phosphodiesterases I and IV, with an IC50 of approximately 10^-5 M.

The substance is widely sold as a supplement on the Internet and has been sold via health food stores, however there appears to be some controversy over the possibility of adverse reaction, and low initial dose is recommended by one retailer, whereas others cheerfully tell you it is safe and wonderful. There is one isolated claim of severe reaction, a life-threatening condition called agranulocytosis. The patient was in terrible shape and had many other medications. Many studies reported no side effects.

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