Tegaserod

Tegaserod is a 5-HT4 agonist used for the management of constipation-predominant irritable bowel syndrome (IBS). Tegaserod is also approved to help relieve the abdominal discomfort, bloating and constipation of Chronic Constipation. It is currently marketed by Novartis under the trade names Zelnorm® (outside the US) or Zelmac (in the US).

A slow-moving digestive system may be the cause of Chronic Constipation or Irritable Bowel Syndrome with Constipation. It can result in the "ABC" symptoms:

Abdominal discomfort: Cramps, twinges or sharp aches that may be in several locations or change location.

Bloating

: A full, tight feeling in the abdomen often caused by excessive gas in the intestines. The abdomen may appear distended, as if heavy and full.

Constipation: This bowel pattern is different for everyone, but could include infrequent bowel movements, hard or lumpy stools, difficulty in passing stools, inability to have a bowel movement, incomplete elimination, straining with a bowel movement or any of these in combination.

Tegaserod is a motility stimulant. Therapeutic effect is achieved through activation of 5-HT4 receptors of the enteric nervous system in the gastrointestinal tract. Tegaserod stimulates gastrointestinal motility and the peristaltic reflex, and possibly also reduces abdominal pain (Rossi, 2004).

Source: wikipedia GFDL

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