Primary Amyloidosis

Amyloidosis is a disorder in which insoluble protein fibers (amyloid) are deposited in tissues and organs, impairing their function.

The cause of primary amyloidosis is unknown.

Signs and symptoms of amyloidosis depend on which primary organ(s) the amyloid deposits occur in.

Primary Amyloidosis Symptoms:

Fatigue
Weight loss
Shortness of breath
Faints
Numbness of hands and feet (Paraesthesia)
Diarrhoea
Swelling of the extremities (oedema)
Enlarged tongue (macroglossia)
Irregular heart rhythm
Pupura around eyes

Treatment:

Patients with primary amyloidosis may respond to chemotherapy directed at the abnormal plasma cells. Autologous stem cell transplanation may be used, similar to the treatment for multiple myeloma.

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