What is gluten sensitive idiopathic neuropathy?

Gluten sensitive idiopathic neuropathy is a disease where gluten can trigger problems in the brain, spinal cord, and peripheral nerves. This can happen because gliadins and glutelins can pass into the bloodstream without having to be digested into very small amino acids first.

Symptoms include migraines and headaches, burning or tingling in their hands or feet, loss of sensation, memory loss and possible mood changes, and epilepsy. Cerebellar ataxia is a sign of poor coordination of muscle movements, and might be present. You may have impaired movements and balance and might take unequal and unbalanced steps when moving, and might not be able to coordinate different parts of your body together. You might also have difficulty doing rapid, alternating, repetitive movements (dysdiadochokinesia).

IgG and IgA anti-gliadin antibodies are involved, and it is mainly a reaction to alpha and beta gliadins.

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